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At ADA 2025, the SOUL trial revealed that oral semaglutide (Rybelsus) reduced the risk of major cardiovascular eventslike heart attack, stroke, and CV deathby 14% over ~4 years in type 2 diabetes GLP 1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents, and hypothalamus for controlling glycemia and feeding American Journal of Physiology Cell Physiology American Physiological Society Zepbound vs. Wegovy: Which Weight Loss Treatment Comes Out on Top? 7 Steps to Start Oral Semaglutide with HSA FSA Benefits in 2026
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.7 ★★★★★
Based on 423 reviews
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Product Reviews
★★★★★ 4
Okay serum, not as good as the cream though
I am obsessed with the cream version of this so I thought I’d give this a try. The dropper top allows for easy application. The formula is light and non greasy and absorbs easily. No harsh fragrances. I would use it when I had eczema flares on my face and feel like it didn’t work near as well in helping with skin irritation as the cream does. As of now I don’t use it as part of my regular skin care. Do I think it’s a bad product? No, but it didn’t really work wonders for me. Not sure I would purchase again.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Helps with redness and softens skin
I have sensitive, mild rosacea skin. Had a facial recently and the aesthetician suggested I get a serum to help with moisturizer as I am almost 40. I’ve tried a lot of serums and either they are sticky and not really hydrating or break my skin out in a rash. This serum is amazing. Helps calm the redness in my cheeks and my skin is moisturized and soft all day. It feels a little sticky at first but it goes away. I apply in this order OSEA sea mineral mist toner to prep the skin, this serum and top off with Chanel La Solution 10 for sensitive skin.
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Reviewed in the United States on December 27, 2025
★★★★★ 5
Sensitive skin
Such a good product. I use after micro needling when skin is sensitive. Also a great product to use as a barrier serum when starting tretinoin cream.
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Reviewed in the United States on April 24, 2026
★★★★★ 5
Saved my skin during an eczema flare up
This saved my skin!
I had an eczema flare on my face, and my usual products weren’t working. A friend recommended the Avene brand and within 3 days of using this rescue barrier serum, my flare was almost completely gone! This saved my face!
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Reviewed in the United States on April 11, 2026
★★★★★ 1
PLEASE REVIEW — FORMULA CHANGED!!!
I wish I would’ve posted a review PRIOR to the formula changing but just know that I LOVED this serum. I’ve struggled with hormonal acne (PCOS) and eczema for as long as I can remember. Finally, last summer my dermatologist put me on (3) different RX including Spironolactone and Accutane. I was so tired so I stopped everything except for CeraVe cleanser, retinol (Tretinoin) and CeraVe healing ointment. My made up skin routine was working until I used too much Tretinoin and burned my face. I had read great reviews about this product so I thought, I might as well try it — and IT WORKED! I’ve been using this product for almost a year and I loved it. However, 3 weeks ago when I ordered it, I noticed the bottle had a green tint. I could tell after one use that the feel of the serum was different, more watery, not as thick as it used to be. The smell was also different. Still, I kept using it for nearly 2 weeks and I experienced 2 breakouts! Sure enough, I stopped the product and within a few days, my skin was back to normal. I am very upset because as someone who has extremely sensitive skin, this worked but unfortunately, the new formula isn’t for me.
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Reviewed in the United States on May 14, 2026
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